As an Assistant Professor of Pharmacology and Toxicology at Ahram Canadian University, I bring a wealth of expertise in neuropharmacology, hepatotoxicity, nephrotoxicity, cardiotoxicity, chemotherapeutic agents, and the safety of drugs and chemicals. With a Ph.D. from Cairo University, my research has focused on innovative therapeutic strategies to mitigate drug-induced liver injuries and other toxicological effects earned the Best Ph.D. Thesis Award at the 2nd ACU International Pharmaceutical Conference in 2018. I have extensive experience in teaching, securing research funding, and leading various academic and research initiatives. My work is published in numerous high-impact international journals, and I am dedicated to advancing pharmaceutical sciences through both education and cutting-edge research. Additionally, I have played a significant role in several administrative positions, including directing the Animal House and participating in the Quality Assurance Unit. I have also served on many committees, such as the Central Research Laboratory, Field Training, Transferred Students, and Struggling Students committees. My dedication to advancing pharmaceutical sciences is reflected in my commitment to both education and pioneering research, aiming to contribute meaningful advancements in the field.
PhD of Pharmacology and toxicology, Faculty of Pharmacy, Cairo University, September 2018. Thesis entitled: Protective effects of zafirlukast and vincamine against tamoxifen-induced liver injury in rats" Master of Pharmacology and toxicology, Faculty of Pharmacy, Cairo University, February 2016. The thesis was entitled: “A study of the possible neuroprotective effects of simvastatin and curcumin in l-methionine-induced vascular dementia in rats” Bachelor of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy, Ahram Canadian University, May 2010, Excellent with GPA 3.78.
El-Dessouki AM, Alzokaky AA, Raslan NA, Ibrahim S, Salama LA, Yousef EH. Piracetam mitigates nephrotoxicity induced by cisplatin via the AMPK-mediated PI3K/Akt and MAPK/JNK/ERK signaling pathways. Int Immunopharmacology. 2024 Jun 22;137:112511. Antar SA, Abdo W, Helal AI, Abduh MS, Hakami ZH, Germoush MO, Alsulimani A, Al-Noshokaty TM, El-Dessouki AM, ElMahdy MK, Elgebaly HA. Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice. Life Sciences. 2024 May 4:122688. El-Gamil DS, Zaky MY, Maximous PM, Sharaky M, El-Dessouki AM, Riad NM, Shaaban S, Abdel-Halim M, Al-Karmalawy AA. Exploring chromone-2-carboxamide derivatives for triple-negative breast cancer targeting EGFR, FGFR3, and VEGF pathways: Design, synthesis, and preclinical insights. Drug development research. 2024 Aug;85(5):e22228. Hefny SM, El-Moselhy TF, El-Din N, Giovannuzzi S, Bin Traiki T, Vaali-Mohammed MA, El-Dessouki AM, Yamaguchi K, Sugiura M, Shaldam MA, Supuran CT. Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles. Journal of Medicinal Chemistry. 2024. Tawfik HO, Mousa MH, Zaky MY, El-Dessouki AM, Sharaky M, Abdullah O, El-Hamamsy MH, Al-Karmalawy AA. Rationale design of novel substituted 1, 3, 5-triazine candidates as dual IDH1 (R132H)/IDH2 (R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations. Bioorganic Chemistry. 2024 May 21:107483. Hefny SM, El-Moselhy TF, El-Din N, Ammara A, Angeli A, Ferraroni M, El-Dessouki AM, Shaldam MA, Yahya G, Al-Karmalawy AA, Supuran CT. A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments. European Journal of Medicinal Chemistry. 2024 May 24:116527. Shaldam MA, Mousa MH, Tawfik HO, El-Dessouki AM, Sharaky M, Saleh MM, Alzahrani AY, Moussa SB. Muti-Target Rationale Design of Novel Substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide Candidates as Telomerase/JAK1/STAT3/TLR4 Inhibitors: Preclinical In vitro and In vivo Investigations. Bioorganic Chemistry. 2024(Accepted). El-Dessouki AM, Alzokaky AA, Raslan NA, Ibrahim S, Alwakeel AI, Yousef EH, 2024. Febuxostat protects from doxorubicin induced hepatotoxicity in rats via regulation of NF-kB/NLRP3 inflammasome and Sirt-1/AMPK pathways. International Immunopharmacology. 2024 July (Accepted). Al-Karmalawy AA, Mousa MH, Sharaky M, Mourad MA, El-Dessouki AM, Hamouda AO, et al. Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. Journal of Medicinal Chemistry. 2023; 67:492-512. Alzokaky AA, Abdelkader EM, El‐Dessouki AM, Khaleel SA, Raslan NA. C‐phycocyanin protects against ethanol‐induced gastric ulcers in rats: Role of HMGB1/NLRP3/NF‐κB pathway. Basic & Clinical Pharmacology & Toxicology. 2020 Oct;127(4):265-77. El-Dessouki AM, and Awad AS, 2019. Boswellic acid ameliorates myocardial injury induced by renal ischemia/reperfusion” at the 2nd ACU international pharmaceutical conference, Faculty of Pharmacy, Ahram Canadian University. El-Dessouki AM, El Fattah MA, Awad AS and Zaki HF, 2018. Zafirlukast and vincamine ameliorate tamoxifen-induced oxidative stress and inflammation: Role of the JNK/ERK pathway. Life sciences, 202, pp.78-88. El-Dessouki AM, El Fattah MA, Awad AS and Zaki HF, 2017. Neuroprotective effects of simvastatin and cilostazol in L-methionine-induced vascular dementia in rats. Molecular neurobiology, 54(7), pp.5074-5084. El-Dessouki AM, El Fattah MA, Awad AS and Zaki HF, 2016. The possible neuroprotective effect of Simvastatin on L-Methionine-induced vascular dementia in rats” at the 6th international Scientific Conference of Faculty of Pharmacy, Cairo University.
